Endocrine Abstracts

Aging is associated with an increase in all the components of the metabolic syndrome and decline in the endocrine axis. We asked if healthy centenarians are over-represented with phenotype and genotype for exceptional longevity that protects them from the endocrine causes of aging. For that, we recruited a genetically homogenous population of unrelated ashkenazi jews with exceptional longevity (n~450). To validate the genetic and physiological findings we also recruited...